Alleviation of Opioid Withdrawal by Cannabis and Delta-9-Tetrahydrocannabinol: A Systematic Review of Observational and Experimental Human Studies

Lit review
by
De Aquino, Joao P. et al

Release Date

2022

Geography

USA

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

The therapeutic benefits of cannabinoids remain unclear, especially when weighted against their adverse effects.

Findings/Key points

Although there is preliminary evidence that cannabis and its main psychoactive constituent, THC, may alleviate opioid withdrawal, these effects are likely to have a narrow therapeutic window. Further, the potential of cannabinoids to alleviate opioid withdrawal is determined by complex interactions between patient characteristics and pharmacological factors.

Keywords

Withdrawal
Clinical guidance