The association between opioid prescribing and opioid-related mortality within neighborhoods in Ontario, Canada: a case control study

Original research
by
Ladha, Karim S. et al

Release Date

2022

Geography

Canada

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

This study aimed to assess the relationship between neighbourhood-level opioid prescription rates and opioid-related mortality amongst individuals without an opioid prescription.

Findings/Key points

There was no significant association between the total volume of opioid prescriptions dispensed in a dissemination area and opioid-related mortality. In sub-group analyses stratifying the cohort into prescription and non-prescription opioid related mortality, the amount of prescriptions dispensed was positively associated with prescription opioid related mortality. There was also a significant inverse association between increased total volume of opioids dispensed and non-prescription opioid mortality.

Design/methods

Nested case-control study using data in Ontario from 2013-2019. After matching, there were 2,401 cases and 8,813 controls.

Keywords

Mortality
Hesitancy of prescribers
About prescribers
Outcomes
Diversion