Association Between Increased Dispensing of Opioid Agonist Therapy Take-Home Doses and Opioid Overdose and Treatment Interruption and Discontinuation

In Ontario, Canada, during the COVID-19 pandemic, dispensing of increased take-home doses of OAT was significantly associated with lower rates of treatment interruption and discontinuation among some subsets of patients, and there were no statistically significant increases in opioid-related overdoses, although the findings may be susceptible to residual confounding and should be interpreted cautiously.