Buprenorphine & methadone dosing strategies to reduce risk of relapse in the treatment of opioid use disorder

Original research
par
Rudolph, Kara E. et al

Date de publication

2022

Géographie

USA

Langue de la ressource

English

Texte disponible en version intégrale

Non

Open Access / OK to Reproduce

Non

Évalué par des pairs

Yes

L’objectif

We estimated the extent to which different dosing strategies would affect risk of relapse over 12 weeks of treatment, separately for BUP-NX and methadone.

Constatations/points à retenir

For BUP-NX, increasing dose following the hybrid strategy both resulted in the lowest risk of relapse. For methadone, holding dose constant resulted in greatest risk of relapse; the other three strategies performed similarly.

La conception ou méthodologie de recherche

Secondary analysis of three trials

Mots clés

Substitution/OAT
Outcomes