Characterizing prescription opioid, heroin, and fentanyl initiation trajectories: A qualitative study

Original research
by
Perdue, Tasha et al

Release Date

2023

Geography

USA

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

We understand the current crisis of overdose deaths to be driven by widespread opioid use, characterized by distinct ‘waves’ of drug use. The first wave was driven by prescription opioids, the second by heroin, and the third by illicit, non-pharmaceutical fentanyl and fentanyl analogues (henceforth, fentanyl). The purpose of this study is to describe opioid initiation within each of the three waves from the perspective of people who use illicit opioids, with a focus on emerging pathways into fentanyl use.

Findings/Key points

We noted supply-side changes as influencing trajectories in all three waves. However, we also noted differences in the experiences of prescription opioid and heroin initiation, with these trajectories influenced by pharmacological effects, pain management, curiosity, intergenerational use, pricing, and peers. In comparison, most participants were unaware that they were initiating fentanyl, and many reported overdosing with their first use of fentanyl. We identified a trajectory into fentanyl with limited to no prior heroin use among a few participants.

Design/methods

Surveys & semi-structured interviews (n=60)

Keywords

About PWUD
Illegal drugs