Original research
by
MacDonald, T. et al
Release Date
2022
Geography
Australia
Language of Resource
English
Full Text Available
No
Open Access / OK to Reproduce
No
Peer Reviewed
Yes
Objective
Discontinuation from benzodiazepines can be problematic for patients and may result in a withdrawal syndrome, which can be protracted and last months to years.
Findings/Key points
Self-reported rates of abstinence from benzodiazepines at three months was between 46.2% and 61.5%. Flumazenil may yield greater success than benzodiazepine tapering from high dose (>30 mg diazepam equivalent) benzodiazepine use.
Design/methods
26 participants received low-dose subcutaneous flumazenil infusions (4 mg/24 h for approximately eight days) as part of a randomised control crossover trial.
Keywords
Clinical guidance
Overdose
Outcomes
