Associations of Methadone and BUP/NX Dose Titration Patterns With Retention in Treatment and Opioid Use in Individuals With Prescription-Type Opioid Use Disorder: Secondary Analysis of the OPTIMA Study

Original research
by
Bakouni, Hamzah et al

Release Date

2024

Geography

Canada

Language of Resource

English

Full Text Available

No

Open Access / OK to Reproduce

No

Peer Reviewed

Yes

Objective

We describe methadone and BUP/NX titration patterns and their associations with treatment outcomes among individuals with a prescription-type opioid use disorder (OUD).

Findings/Key points

Sustained methadone dose titration, when indicated, may help increase retention, whereas faster dose titration for methadone may help decrease opioid use.

Design/methods

We used data from a 24-week open-label, multicenter randomized controlled trial, including N = 167 participants aged 18–64 years old with prescription-type OUD who received at least a first dose of treatment

Keywords

Substitution/OAT
Outcomes